Passing motorists, including an Associated Press photographer, noticed a plume of smoke rising beside Interstate 10 in Mississippi and pulled over to help the two women, who were trapped inside the wrecked SUV.
The motorists first pulled the disabled girl from the burning vehicle, but had trouble getting the woman out.
As the motorists attempted to save the mother, others tried to extinguish the fire using a hose from a cement mixer and fire extinguishers from trucks. The motorists were able to pull the woman from the vehicle and extinguish the fire before rescue personnel arrived.
The woman was airlifted from the scene with a severe head injury. The disabled girl suffered minor injuries and was taken to the hospital.
Watch video, courtesy of the Associated Press, below: