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Pioneering lab work aims to smash women’s fertility barrier

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PARIS — An experiment that produced human eggs from stem cells could one day be a boon for women who are desperate to have a baby, according to a study published on Sunday.

The work sweeps away the belief that a woman has only a limited stock of eggs and replaces it with the theory that the supply is continuously replenished from precursor cells in the ovary, its authors said.

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“The prevailing dogma in our field for the better part of the last 50 or 60 years was that young girls at birth were given a bank account of eggs at birth that’s not renewable,” said Jonathan Tilly, director of the Vincent Center for Reproductive Biology at Massachusetts General Hospital, who led the research.

“As they become mature and become a woman, they use those eggs up (and) the ovaries will fail when they enter menopause.”

Tilly first challenged the “bank account” doctrine eight years ago, suggesting female mammals continue producing egg-making cells into adulthood rather than from a stock acquired at birth.

His theory ran into a firestorm.

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Other scientists challenged the accuracy of his experiments or dismissed their conclusions as worthless, given that they had only been conducted on lab mice.

But the new work, said Tilly, not only confirms his controversial idea, but takes it farther.

In it, his team isolated egg-producing stem cells in human ovaries and then coaxed them into developing oocytes, as eggs are called.

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Building on a feat by Chinese scientists, they pinpointed the oocyte stem cells by using antibodies which latched onto a protein “handle” located on the side of these cells.

The team tagged the stem cells with a fluorescent green protein — a common trick to help figure out what happens in lab experiments.

The cells were injected into biopsied human ovarian tissue which was then grafted beneath the skin of mice.

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Within 14 days, the graft had produced a budding of oocytes. Some of the eggs glowed with the fluorescent tag, proving that they came from the stem cells. But others did not, which suggested they were already present in the tissue before the injection.

Tilly said “the hairs were standing up on my arm” when he saw time-elapse video showing the eggs maturing in a lab dish.

Further work needs to be done to test the viability of the eggs, and little is known about the hormones or other mechanisms by which oocytes emerge from the stem cells.

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But the impact could be far-reaching, Tilly said.

“If we can guide the process correctly, I think it opens up a chance that sometime in the future, we might get to the point of actually having an unlimited source of human eggs,” Tilly said in a video recording released to the press.

“A woman could come in, have a small biopsy taken from her ovary for us to retrieve these cells. Once we get these cells out, we can take a hundred of them and make a million of them.

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“If we can get to the stage of generating functional human eggs outside the body, it would rewrite essentially human assisted reproduction.”

According to a press release issued by Massachusetts General Hospital, Tilly’s team are already exploring the idea of banks where oocyte stem cells can be frozen and stored, and then retrieved when a woman wants to have a baby.

Human eggs are extremely delicate and likely to suffer damage when frozen and thawed, but this risk does not apply to the egg cells that make them, it said.

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Previous work has shown that around one in 10 women of reproductive age is at risk of premature ageing of the ovaries, a finding with repercussions in societies where women opt ever later to become mothers.

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… then let us make a small request. Like you, we here at Raw Story believe in the power of progressive journalism — and we’re investing in investigative reporting as other publications give it the ax. Raw Story readers power David Cay Johnston’s DCReport, which we've expanded to keep watch in Washington. We’ve exposed billionaire tax evasion and uncovered White House efforts to poison our water. We’ve revealed financial scams that prey on veterans, and efforts to harm workers exploited by abusive bosses. We’ve launched a weekly podcast, “We’ve Got Issues,” focused on issues, not tweets. Unlike other news sites, we’ve decided to make our original content free. But we need your support to do what we do.

Raw Story is independent. You won’t find mainstream media bias here. We’re not part of a conglomerate, or a project of venture capital bros. From unflinching coverage of racism, to revealing efforts to erode our rights, Raw Story will continue to expose hypocrisy and harm. Unhinged from corporate overlords, we fight to ensure no one is forgotten.

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2020 Election

Trump campaign mocked after unveiling new red hats: ‘Do you have arm bands as well?’

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President Donald Trump's 2016 "Make America Great Again" hats have been replaced with new "Keep America Great" hats.

Trump re-election campaign manager Brad Parscale modeled one of the hats on Twitter.

Here is some of what people were saying:

https://twitter.com/LazarusLeBaron/status/1165430924093165568

Here I made an arm band design for you pic.twitter.com/inTyqVi2wo

— Christopher Goodwin (@LazarusLeBaron) August 25, 2019

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‘This will not end well’: Far-right extremism expert warns of Trump’s intensifying authoritarianism

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An expert on the far-right in America warned of President Donald Trump's "genuinely dangerous levels" of authoritarianism on Saturday.

Author David Neiwert posted a long Twitter thread on the commander-in-chief's "Social Dominance Orientation" -- and warned it will not end well.

Neiwert is the author of the 2017 book Alt-America: The Rise of the Radical Right in the Age of Trump.

Here is the thread he posted:

https://twitter.com/DavidNeiwert/status/1165428067138846720

https://twitter.com/DavidNeiwert/status/1165428524808724480

https://twitter.com/DavidNeiwert/status/1165429018486702081

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Ilhan Omar trolls GOP lawmakers ‘losing their minds’ over sharing the House floor with three Muslim Democrats

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One of the first Muslim women elected to Congress trolled her GOP colleagues for "losing their minds" over the existence of three Muslims in the House of Representatives.

The three Muslims in Congress are Rep. Ilhan Omar (D-MN), Rep. Rashida Tlaib (D-MI) and Rep. André Carson (D-IN), with Omar and Tlaib being the first to Muslim women in the body

Rep. Mo Brooks (R-AL) worried about the "growing influence" during an appearance on a local radio station.

Intercept columnist Mehdi Hasan posted a link to the interview on Twitter, calling it "open bigotry."

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