Quantcast
Connect with us

Scientists find gene that inhibits pancreas cancer spread

Published

on

PARIS — Scientists have identified a gene that slows the spread of pancreatic cancer tumours, paving the way for targeted treatment of one of the deadliest forms of the disease, said a paper published Sunday.

After discovering the gene dubbed USP9X at work in a study of pancreatic cancer in mice, the international research team found it also played a role in humans.

ADVERTISEMENT

“We looked in human tumour specimens and we found that it was missing in a fraction of patients — the patients that did very poorly … the people who died the fastest,” researcher David Tuveson told AFP.

“Patients that had a low level of the gene expressed … they died very quickly after their operation and the patients who at the end of their life had lots of metastasis (spreading of the cancer), they had also a very low level of this protein.”

The existence of the gene, which is found in all of our cells but goes missing in some tumours, was known before but not its role as a cancer suppressor, said Tuveson.

Three other pancreatic tumour suppressor genes are known to exist, but this is the one whose absence “probably causes metastasis — that is what kills people with pancreas cancer,” said the scientist.

The discovery means that “we can wake up the gene by using drugs” known as epigenetic modulators, he added.

ADVERTISEMENT

“Our observation allows us to potentially treat people that have lost this gene in the pancreas tumours. It allows us to offer a therapy for the patients that actually have the worst prognosis.”

Tuveson said these kinds of drugs have already been developed, “but people haven’t figured out where exactly they would be useful.

“We are proposing that these drugs would be useful in this subset of pancreas cancer patients.”

ADVERTISEMENT

Pancreatic cancer kills about 96 percent of its victims within five years of diagnosis, one of the lowest cancer survival rates.

Early diagnosis is difficult, so the disease is often discovered only after it has already spread.

ADVERTISEMENT


Report typos and corrections to: [email protected].
READ COMMENTS - JOIN THE DISCUSSION
Continue Reading

Breaking Banner

Here is how the 99% can force the 1% to defeat COVID-19

Published

on

By

The government's response to the pandemic has further enriched the wealthy, while everyday people, especially Black and Brown workers, face sickness, death, and destitution. Government handouts to the rich are unsurprising, since they repeat the century-old pattern of "rescue packages", but another pattern is more perplexing: why have business leaders not stepped up to demand a robust public health response, which would ultimately be in their own self-interest? The titans of industry have mostly stood by in the face of Trump's criminal negligence, which has devastated much of the 99% but also endangers the wealthy.

Continue Reading

Breaking Banner

Trump Organization planning ‘high-end’ retirement community — with 225 properties — on foreign soil: report

Published

on

The Trump Organization is planning a massive real estate development, according to a new report by Martyn McLaughlin in The Scotsman.

"In what would be one of the most ambitious and expensive foreign projects undertaken by Donald Trump’s family business since he assumed the presidency, his company has commissioned a detailed masterplan to develop as many as 225 properties, as well as leisure facilities and shops, on an expanse of rolling farmland adjacent to Turnberry’s lauded Ailsa course, a four-time host of golf’s Open Championship," the Scottish newspaper reported.

Continue Reading
 

Breaking Banner

WATCH: Video shows how Trump makes his caddie hang on to the back of the golf cart

Published

on

Despite the ongoing coronavirus pandemic and economic catastrophe, the leader of the free world spent the weekend golfing at his private, for-profit golf course in Virginia.

For the second day in a row, Donald Trump's presidential motorcade traveled to Trump National Golf Club in Sterling, Virginia.

"Today marks the president’s 86th day trip to Sterling," reported HuffPost correspondent S.V. Dáte, who was the White House pool reporter for print covering the day's events.

Continue Reading
 
 
You need honest news coverage. Help us deliver it. Join Raw Story Investigates for $1. Go ad-free.
close-image