Quantcast
Connect with us

Study: Chemotherapy can backfire and boost cancer growth

Published

on

Cancer-busting chemotherapy can cause damage to healthy cells, which triggers them to secrete a protein that sustains tumor growth and resistance to further treatment, a study said Sunday.

Researchers in the United States made the “completely unexpected” finding while seeking to explain why cancer cells are so resilient inside the human body when they are easy to kill in the lab.

They tested the effects of a type of chemotherapy on tissue collected from men with prostate cancer, and found “evidence of DNA damage” in healthy cells after treatment, the scientists wrote in Nature Medicine. Chemotherapy works by inhibiting reproduction of fast-dividing cells such as those found in tumors.

The scientists found that healthy cells damaged by chemotherapy secreted more of a protein called WNT16B which boosts cancer cell survival.

“The increase in WNT16B was completely unexpected,” study co-author Peter Nelson of the Fred Hutchinson Cancer Research Center in Seattle told AFP.

ADVERTISEMENT

The protein was taken up by tumor cells neighboring the damaged cells.

“WNT16B, when secreted, would interact with nearby tumour cells and cause them to grow, invade, and importantly, resist subsequent therapy,” said Nelson.

In cancer treatment, tumors often respond well initially, followed by rapid regrowth and then resistance to further chemotherapy.

ADVERTISEMENT

Rates of tumor cell reproduction have been shown to accelerate between treatments.

“Our results indicate that damage responses in benign cells … may directly contribute to enhanced tumor growth kinetics,” wrote the team.

The researchers said they confirmed their findings with breast and ovarian cancer tumors.

ADVERTISEMENT

The result paves the way for research into new, improved treatment, said Nelson.

“For example, an antibody to WNT16B, given with chemotherapy, may improve responses (kill more tumor cells),” he said in an email exchange. “Alternatively, it may be possible to use smaller, less toxic doses of therapy.”


Report typos and corrections to: [email protected]. Send news tips to: [email protected].
READ COMMENTS - JOIN THE DISCUSSION
Continue Reading

Breaking Banner

Protesters take to the streets outside judge’s home after he approves controversial jail sentence for black judge

Published

on

On Monday, angry crowds of people came to the neighborhood of Hamilton County Common Pleas Court Judge Patrick Dinkelacker after he ordered former judge Tracie Hunter to serve a six-month prison sentence for mishandling a confidential document.

The scenes from the courtroom were dramatic, with Hunter's supporters screaming as she collapsed upon Dinkelacker upholding the sentence, and officers dragging her limp figure from the courtroom:

Continue Reading

Breaking Banner

‘They share staff with the Kremlin’: Maddow roasts Trump’s new favorite right-wing network OANN

Published

on

MSNBC anchor Rachel Maddow roasted One America News Network (OANN) for employing a Kremlin operative to report on United States politics.

"If the Fox News channel is insufficiently pro-Trump for you, you may or may not know there is another boutique little news outlet that is designed specifically for Trump megafans called One America, One America News Network," she explained.

"The Trump White House gave this boutique outfit a hard pass for access to the White House grounds and a permanent seat in the White House briefing room -- remember when the White House used to hold press briefings? They had a seat," she continued.

Continue Reading
 

Breaking Banner

Trump asked right-wing conspiracy theorist congressman to help him pick his next Director of National Intelligence

Published

on

On Monday, Politico reported that President Donald Trump is consulting with Rep. Devin Nunes (R-CA) about who he should consider to replace Director of National Intelligence Dan Coats.

Nunes has led the Republican side of the House Intelligence Committee since 2015 and chaired the committee for four years, despite having no professional qualifications of any kind for that role. Since 2017, he has been known for his stunts and conspiracy theories intended to discredit the Russia investigation and throw suspicion on anyone who looks into Trump's conduct.

Continue Reading
 
 
 

Copyright © 2019 Raw Story Media, Inc. PO Box 21050, Washington, D.C. 20009 | Masthead | Privacy Policy | For corrections or concerns, please email [email protected]

Join Me. Try Raw Story Investigates for $1. Invest in Journalism. Escape Ads.
close-image