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New drug-resistant Salmonella variant behind an epidemic across sub-Saharan Africa

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A deadly version of an intestinal germ has spread through sub-Saharan Africa, helped by genetic mutation and diseases such as HIV that weaken the immune system and expose the body to infection, researchers said Sunday.

The finding comes in a genetic comparison of variants of Salmonella Typhimurium, one of the Salmonella family of stomach bugs.

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In sub-Saharan Africa, a new form of the germ emerged in the southeast of the continent 52 years ago, followed by a second wave, which came out of central Africa 17 years later, the researchers said in a new study published by the journal Nature Genetics.

The variant is the cause of an enigmatic disease called invasive non-typhoidal salmonella (iNTS), which affects Africa far more than other continents.

iNTS kills between 22 and 45 percent of those it infects and is suspected to be transmitted from human to human, previous research has found.

Outside Africa, Salmonella without this variant tend to cause acute diarrhoea but the death rate is less than one percent. And these infections typically occur from contaminated food, not from humans.

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The answer, according to the study, lies in part from genes that Salmonella Typhimurium picked up in Africa which shield it from frontline antibiotics and help it survive in a human host.

The novel strain “is causing a previously unrecognised epidemic” across sub-Saharan Africa, said Chinyere Okoro of the Wellcome Trust Sanger Institute in Britain, who co-authored the study.

“Its genetic makeup is evolving into a more typhoid-like bacteria, able to efficiently spread around the human body.”

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Previous research into iNTS has noted the large numbers of Africans who are co-infected with HIV.

The new study says iNTS may in fact have been powerfully spread by HIV or by anaemia, malaria or malnutrition in children, all of which deplete the body’s defences against a microbial invader.

“The HIV epidemic in sub-Saharan Africa is thought to have begun in a central region and underwent expansion eastwards, a strikingly similar dynamic to that observed for the second iNTS wave,” said Okoro’s colleague, Robert Kingsley.

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“Our findings suggest the current epidemic of iNTS and its transmission across sub-Saharan Africa may have been potentiated by an increase in the critical population of susceptible immune-compromised people.”

The second wave of iNTS began 35 years ago, possibly in the Congo Basin, and early in the event picked up a gene making it resistant to the antibiotic chloramphenicol, the study suggested.

The first documented cases of AIDS occurred in the United States 31 years ago.

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Researchers, though, say HIV circulated in Africa for many years before the disease was uncovered.

It leapt the species barrier to humans from chimps, possibly through contact with bushmeat, around the turn of the century, according to some investigations.

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… then let us make a small request. Like you, we here at Raw Story believe in the power of progressive journalism — and we’re investing in investigative reporting as other publications give it the ax. Raw Story readers power David Cay Johnston’s DCReport, which we've expanded to keep watch in Washington. We’ve exposed billionaire tax evasion and uncovered White House efforts to poison our water. We’ve revealed financial scams that prey on veterans, and efforts to harm workers exploited by abusive bosses. We’ve launched a weekly podcast, “We’ve Got Issues,” focused on issues, not tweets. Unlike other news sites, we’ve decided to make our original content free. But we need your support to do what we do.

Raw Story is independent. You won’t find mainstream media bias here. We’re not part of a conglomerate, or a project of venture capital bros. From unflinching coverage of racism, to revealing efforts to erode our rights, Raw Story will continue to expose hypocrisy and harm. Unhinged from corporate overlords, we fight to ensure no one is forgotten.

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Trump dodges and gives an accidentally revealing answer when confronted on his anti-LGBT policies

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When President Donald Trump was asked Tuesday about whether he supports his administration's anti-LGBT policies — including a new rule that would make it easier for employers to discriminate — he gave what seemed to be an unintentionally revealing answer.

REPORTER: Mr POTUS, your administration has been taking steps to make it easier to discriminate against LGBT people in the workforce. Are you okay with that?

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‘A bullhorn to his white nationalist base’: Progressive Jews hit back after Trump’s anti-Semitic smear

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"This rhetoric from the president is going to get Jews killed. It already has."

Progressive Jews accused President Donald Trump of blaring "straightforward anti-Semitism" after he said from the Oval Office on Tuesday that Jewish Americans who vote for the Democratic Party are either ignorant or disloyal.

The smear, which sparked widespread outrage, came after Trump once again baselessly accused Reps. Rashida Tlaib (D-Mich.) and Ilhan Omar (D-Minn.) of hating Jews and Israel.

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You can expect these 3 authoritarian regimes to help get Trump reelected in 2020

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In the aftermath of the Israeli government’s decision to bar Reps. Ilhan Omar and Rashida Tlaib from visiting Israel and Palestine, the 2020 Democratic presidential contenders rallied around the two congresswomen, and the Israeli government discredited its American supporters.

With a blatant show of support for President Trump’s strategy of racial polarization, Israeli Prime Minister Bibi Netanyahu not only signaled his government’s support for Trump in the 2020 election; he also served to unify an often-fractious party around a more anti-Israel message that resonates across the party’s left-center spectrum.

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