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Study links Paxil to increased breast cancer risk in women

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After developing a faster way to identify drugs and chemicals that may disrupt the balance of hormones in the human body, California scientists have fingered the popular anti-depressant drug Paxil and linked it to a possible increased breast cancer risk.

The study, reported by the Los Angeles Times, found that the popular antidepressant Paxil (chemically known as paroxetine) has a weak “estrogenic effect,” meaning that it may be responsible for cancers in some women. They compared it against 445 other drugs “in wide circulation,” according to the report.

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The particular screening method used to detect hormonal changes after exposure to drugs or chemicals is new. The method also identified two other medications — the antifungals biconazole and oxyconazole — as having an anti-estrogenic effect. This is in opposition to Paxil, meaning it may reduce cancer or the recurrence of cancer in some women. Estrogen is seen playing a role in the growth and recurrence of cancers.

The study builds upon a finding in another Canadian examination of Paxil in 2010. That study found that breast cancer patients who took Paxil were more likely to die of breast cancer if they took it in concert with tamoxifen, an anti-cancer drug.

In the Canadian study, researchers hypothesized that Paxil might block the production of a liver enzyme needed to metabolize tamoxifen.

A 2012 study conducted in Holland also linked Paxil and other selective serotonin reuptake inhibitors (SSRIs) — a popular antidepressant class that includes the drugs Prozac and Zoloft — with increased falls among elderly patients. A 2012 study found Paxil more than doubled the risk of a woman’s child being born with a birth defect that affects breathing.

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Writes the Times:

Last summer, the Food and Drug Administration approved the marketing of a low dose of paroxetine — repackaged under the commercial name Brisdelle — as a nonhormonal treatment for hot flashes and other menopausal symptoms.

About 70% of breast cancers in women are sensitive to estrogen, meaning that the hormone found plentifully in females of child-bearing age contributes to their growth.

The novel screening method… described in a forthcoming issue of the journal Toxicological Sciences, also identified two antifungal medications — biconazole and oxyconazole — as having an anti-estrogenic effect similar to that of medications prescribed to prevent breast cancer and its recurrences in women. Incidental to their intended use in combating fungal infections, those medications inhibit the action of aromatase, an enzyme that converts androgens — hormones more plentiful in males but present in both sexes — into estrogen…

Less surprising, the high-throughput screening mechanism identified bisphenol A — a compound used in the manufacture of plastics and epoxy resins — as an estrogen promoter capable of raising breast cancer risk.

Paxil has been on the market since 1992. According to the Times, almost a quarter of American women in their 40s and 50s take an antidepressant, generally an SSRI.

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[Photo credit: Shutterstock]


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Stephen Colbert rips ‘idiot’ GOP senator for defending Trump’s unconstitutional self-dealing

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"Late Show" host Stephen Colbert returned from New Zealand for a new show that aired Monday evening.

"I have been as far from the insatiable black hole of news that is Donald Trump as you can get on this planet.

I've heard there have been some developments over the last 10 days that did not go well for Donnie,"

The host ripped Trump's 71-minute press conference.

"Seventy-one minutes is not a press conference, it's a one man show," he explained. "If you liked 'Fleabag,' you'll love Donald Trump in 'Douchebag,'" he said.

[caption id="attachment_1555275" align="aligncenter" width="800"] ‘The Late Show’ graphic (screengrab)[/caption]

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Texas Republicans are abandoning the state’s GOP Speaker: ‘We no longer support him’

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Some of the most powerful Texas House Republicans said Monday they no longer support GOP Speaker Dennis Bonnen, marking the biggest blow yet to his political future amid the fallout from a secret recording released last week by a hardline conservative activist.

Five Republicans considered senior members of the lower chamber issued a statement withdrawing support for him: State Reps. Four Price of Amarillo, Dan Huberty of Houston, Lyle Larson of San Antonio, Chris Paddie of Marshall and John Frullo of Lubbock.

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Donald Trump is making a mockery of Marco Rubio — and the Florida senator is letting him

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Sen. Marco Rubio was once one of Donald Trump’s most formidable opponents; now, the Florida senator bends over backward to excuse the president’s corruption.

In 2016, Rubio and Trump sparred frequently on the Republican primary debate stage. Trump picked the uninspired nickname “Little Marco” for the senator, which didn’t seem to do much damage on its own, but Rubio never gained the momentum or strength that his backers hoped would prove to be strong enough to take down the reality TV candidate. As Rubio grew desperate, he launched one of his most memorable and pitiful attacks by stooping to his opponent’s level, implying that Trump had a small penis. It was more of an embarrassing moment for Rubio than anyone else, though Trump helped himself with a crude rejoinder.

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