Quantcast
Connect with us

Study links Paxil to increased breast cancer risk in women

Published

on

After developing a faster way to identify drugs and chemicals that may disrupt the balance of hormones in the human body, California scientists have fingered the popular anti-depressant drug Paxil and linked it to a possible increased breast cancer risk.

The study, reported by the Los Angeles Times, found that the popular antidepressant Paxil (chemically known as paroxetine) has a weak “estrogenic effect,” meaning that it may be responsible for cancers in some women. They compared it against 445 other drugs “in wide circulation,” according to the report.

ADVERTISEMENT

The particular screening method used to detect hormonal changes after exposure to drugs or chemicals is new. The method also identified two other medications — the antifungals biconazole and oxyconazole — as having an anti-estrogenic effect. This is in opposition to Paxil, meaning it may reduce cancer or the recurrence of cancer in some women. Estrogen is seen playing a role in the growth and recurrence of cancers.

The study builds upon a finding in another Canadian examination of Paxil in 2010. That study found that breast cancer patients who took Paxil were more likely to die of breast cancer if they took it in concert with tamoxifen, an anti-cancer drug.

In the Canadian study, researchers hypothesized that Paxil might block the production of a liver enzyme needed to metabolize tamoxifen.

A 2012 study conducted in Holland also linked Paxil and other selective serotonin reuptake inhibitors (SSRIs) — a popular antidepressant class that includes the drugs Prozac and Zoloft — with increased falls among elderly patients. A 2012 study found Paxil more than doubled the risk of a woman’s child being born with a birth defect that affects breathing.

Writes the Times:

ADVERTISEMENT

Last summer, the Food and Drug Administration approved the marketing of a low dose of paroxetine — repackaged under the commercial name Brisdelle — as a nonhormonal treatment for hot flashes and other menopausal symptoms.

About 70% of breast cancers in women are sensitive to estrogen, meaning that the hormone found plentifully in females of child-bearing age contributes to their growth.

The novel screening method… described in a forthcoming issue of the journal Toxicological Sciences, also identified two antifungal medications — biconazole and oxyconazole — as having an anti-estrogenic effect similar to that of medications prescribed to prevent breast cancer and its recurrences in women. Incidental to their intended use in combating fungal infections, those medications inhibit the action of aromatase, an enzyme that converts androgens — hormones more plentiful in males but present in both sexes — into estrogen…

Less surprising, the high-throughput screening mechanism identified bisphenol A — a compound used in the manufacture of plastics and epoxy resins — as an estrogen promoter capable of raising breast cancer risk.

Paxil has been on the market since 1992. According to the Times, almost a quarter of American women in their 40s and 50s take an antidepressant, generally an SSRI.

[Photo credit: Shutterstock]

ADVERTISEMENT


Report typos and corrections to: [email protected].
READ COMMENTS - JOIN THE DISCUSSION
Continue Reading

Breaking Banner

Trump supporters lose their minds when church shows Nativity scene in immigrant cages

Published

on

MAGA supporters are losing their minds after a photo of the Nativity scene at Claremont United Methodist Church was posted to Facebook.

The scene depicts Mary, Joseph, and the baby Jesus separated and put in their own cages, a reference to the families separated at the U.S.-Mexico border. Inside the church, the family is shown as reunited.

Senior minister Karen Clark Ristine shared the image on Facebook with the message hoping that everyone in the United States could see the photo and read the story for Christmas.

"The theological statement posted with the nativity: In a time in our country when refugee families seek asylum at our borders and are unwillingly separated from one another, we consider the most well-known refugee family in the world," she wrote. "Jesus, Mary, and Joseph, the Holy Family. Shortly after the birth of Jesus, Joseph and Mary were forced to flee with their young son from Nazareth to Egypt to escape King Herod, a tyrant. They feared persecution and death."

Continue Reading

Breaking Banner

Columnist nails Republicans for only caring about Hunter Biden now that his father is running for president

Published

on

One of the critical questions that must be answered by Republicans, according to one Washington Post columnist, is why they didn't care about Hunter Biden's position at Burisma for so many years.

In a Sunday piece, James Downie asked why Republicans didn't do anything about Hunter Biden five years ago when it was first revealed that vice president's son was on the board of a Ukraine energy company. The House and the Senate were being run by Republicans until this year. They haven't had problems with other partisan investigations against high-profile leaders. There were ten investigations into the Benghazi attacks, three hearings, 29 witnesses, and former Secretary of State Hillary Clinton testified for 11 hours. Yet, it was only after Joe Biden announced he was running against President Donald Trump that Republicans discovered an issue.

Continue Reading
 

Breaking Banner

Republican staffer caught spying on Democrats during Judiciary Committee meetings

Published

on

A Republican staffer from the Ways and Means committee was caught spying on Democrats during their work over the weekend.

According to a Judiciary Committee source, the female staffer was ultimately discovered and ran out of the committee room once it was discovered she was there, tweeted Olivia Beavers, a writer at "The Hill."

"A Judiciary source says the committee, which has been practicing for their Monday impeachment hearing this whole weekend, came across a female GOP Ways and Means staffer in the hearing room today, but that she ran out once discovered," she tweeted.

https://twitter.com/Olivia_Beavers/status/1203784487559213056

Continue Reading