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Stanford researchers discover how to trick cells into believing they are younger

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Researchers at Stanford Medical Center have discovered a means to extend the length of telomeres — the protective caps at the tips of chromosomes responsible for aging — io9’s George Dvorsky reports.

The telomere, much like an aglet on a shoelace, binds the chromosome and prevents it from unraveling. Human telomeres begin at approximately 8,000 to 10,000 nucleotides long, but they get shorter with each cell division — which is the process responsible for aging.

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But the scientists at Stanford have found a way to deliver messenger RNA that encodes a telomere-extending protein. The result was that the cells whose chromosomes were treated with this RNA behaved as if they were much younger.

“We have found a way to lengthen human telomeres by as much as 1,000 nucleotides, turning back the internal clock in these cells by the equivalent of many years of human life,” Helen Blau wrote in a press release.

“This new approach paves the way toward preventing or treating diseases of aging,” she said. “There are also highly debilitating genetic diseases associated with telomere shortening that could benefit from such a potential treatment.”

“It might not be the Fountain of Youth to keep us young forever, but this discovery is a real shot in the arm. This work is a game-changer,” Gerald Weissmann, editor-in-chief of the journal that published the study, added.

“In the short term it will help us to understand how aging affects the molecular machinery of cells. In the long-term, the sky’s the limit. Biologists have long guessed that the key to a longer lifespan is figuring out how to extend telomeres. Helen Blau and her colleagues have just done that.”

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Critics of sweeping policy changes always make one huge mistake: Robert Reich

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In last Wednesday night’s Democratic debate, former South Bend mayor Pete Buttigieg charged that Senator Bernie Sanders’ policy proposals would cost $50 trillion. Holy Indiana.

Larry Summers, formerly chief White House economic advisor for Barack Obama, puts the price tag at $60 trillion. “We are in a kind of new era of radical proposal,” he told CNN.

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2020 Election

Bernie Sanders campaign accepts apology from MSNBC anchor Chris Matthews: ‘We got to get past it’

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MSNBC anchor Chris Matthews on Monday apologized to the Bernie Sanders campaign after comparing his dominance in the first three states of the 2020 presidential nomination to the fall of France to the Nazis in World War II.

Sanders senior advisor Chuck Rocha was asked on Fox News for response.

"Look, we all get hot and say things in the moment, I'm glad Chris apologized," Rocha said. "We got to move on and get past it, I'm glad he said what he had to say, I'm tired of folks on Twitter fighting with each other, it's time to win this election."

https://twitter.com/Acyn/status/1232099452531331072

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2020 Election

‘Breathtaking fiscal hypocrisy’ of the GOP may win Trump reelection: Nobel economist

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Donald Trump was blasted for his economic policies by Nobel Prize-winning economist Paul Krugman -- who worries it just might work to get the president reelected.

"It may have slipped by you, but last week Donald Trump suggested that he may be about to give U.S. farmers — who have yet to see any benefits from his much-touted trade deal with China — another round of government aid," Krugman wrote in The New York Times. "This would be on top of the billions in farm aid that Trump has already delivered, costing taxpayers several times as much as Barack Obama’s auto bailout — a bailout Republicans fiercely denounced as 'welfare' and 'crony capitalism' at the time."

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