An inexpensive blood test could one day tell doctors whether an infection is caused by a virus or a bacteria, and help prevent unwarranted prescribing of antibiotics, researchers said Wednesday.
The diagnostic test, described in the peer-reviewed journal Science Translational Medicine, is being developed by the Stanford University School of Medicine in California.
“A lot of times you can’t really tell what kind of infection someone has,” said lead author Timothy Sweeney, an engineering research associate with the Stanford Institute for Immunity, Transplantation and Infection.
“If someone comes into the clinic, a bacterial or a viral infection often looks exactly the same.”
The new test, which is not yet on the market, works by identifying seven human genes whose activity changes during an infection, and whose pattern of activity can reveal whether an infection is bacterial or viral.
“Many diagnostics focus on trying to find bacteria in the bloodstream, but most infected people don’t have bloodstream infections, meaning such tests aren’t helpful,” Sweeney told AFP.
“In contrast, our test can detect an infection anywhere in the body by ‘reading the immune system,'” he added.
“It is also significantly better — three times better — at ruling out bacterial infections compared to the next-best similar test, procalcitonin.”
The idea for such a test came after research published last year showed “a common response by the human immune system to multiple viruses that is distinct from that for bacterial infections,” said senior author Purvesh Khatri, assistant professor of medicine.
If further tests show that it works and is cost-effective, the test could be a useful tool in preventing the rise of antibiotic-resistant bacterial pathogens.
Often, patients are prescribed antibiotics because the drugs are cheap.