The Dow Jones Industrial Average sank more than 2 percent at the open on Wednesday as big U.S. manufacturers, grain merchants and chipmakers bore the brunt of a deepening trade conflict between China and the United States.
The S&P 500 .SPX opened below its 200-day moving average, a key technical level.
The Dow fell 506.21 points, or 2.11 percent, to 23,527.15. The S&P lost 40.75 points, or 1.56 percent, to 2,573.7. The Nasdaq Composite .IXIC dropped 126.95 points, or 1.83 percent, to 6,814.33.
Reporting by Sruthi Shankar in Bengaluru; Editing by Savio D'Souza