Specific brain patterns related to excessive self-blame might be important for predicting depression treatment outcomes

A new study published in NeuroImage: Clinical has found that certain patterns in the brain related to excessive self-blame are important for predicting the outcome of treatment in depression patients who haven’t responded well to standard treatments. Only about half of the patients with major depressive disorder (MDD) respond to antidepressant treatment, and a significant number of patients fail to achieve remission even after multiple treatment attempts. The new study sought to identify neural markers related to self-blame in MDD and understand their associations with treatment outcomes. By u...