Unlike Tuskegee experiments, doctors intentionally infected patients with gonorrhea, syphilis, encouraged them to spread the STDs and many were left untreated

Update at bottom: Secretary of State Hillary Clinton and Health Secretary Kathleen Sebelius call study conducted between 1946 and 1948 in Guatemala 'clearly unethical' and 'reprehensible'; at least one patient died

Nazi scientists and doctors at Buchenwald and other concentration camps conducted sinister experiments on Jewish prisoners during the Holocaust, and America has its own skeletons involving medical experimentation (Photograph taken from www.HolocaustResearchProject.org).

Nearly forty years ago, the Associated Press reported, "For 40 years, the US Public Health Service has conducted a study in which human guinea pigs, not given proper treatment, have died of syphilis and its side effects. The study was conducted to determine from autopsies what the disease does to the human body."

In 2002, NPR's Alex Chadwick noted,

The Public Health Service, working with the Tuskegee Institute, began the study in 1932. Nearly 400 poor black men with syphilis from Macon County, Ala., were enrolled in the study. They were never told they had syphilis, nor were they ever treated for it. According to the Centers for Disease Control, the men were told they were being treated for "bad blood," a local term used to describe several illnesses, including syphilis, anemia and fatigue.

For participating in the study, the men were given free medical exams, free meals and free burial insurance.

At the start of the study, there was no proven treatment for syphilis. But even after penicillin became a standard cure for the disease in 1947, the medicine was withheld from the men. The Tuskegee scientists wanted to continue to study how the disease spreads and kills. The experiment lasted four decades, until public health workers leaked the story to the media.

But, apparently, the Tuskegee experiments were more "benign" than other related projects.

"US government medical researchers intentionally infected people in Guatemala, including institutionalized mental patients, with gonorrhea and syphilis without their knowledge or permission more than 60 years ago," Robert Bazell, the Chief science and health correspondent for NBC News, reports. "Many of those infected were encouraged to pass the infection onto others as part of the study. About one third of those who were infected never got adequate treatment."

On Friday, Secretary of State Hillary Clinton and Health and Human Services Secretary Kathleen Sebelius are expected to offer extensive apologies for actions taken by the U.S. Public Health Service.

The apology will be to Guatemala and Hispanic residents of the United States, according to officials.

The first public discussion will be a telebriefing with Dr. Francis Collins, director of the National Institutes of Health and Arturo Valenzuela, Assistant Secretary of State for Western Affairs around 11 a.m. ET.

Susan M Reverby, a professor of women's studies at Wellesley College, uncovered the experimentation in an article titled "Normal Exposure' and Inoculation Syphilis: A PHS 'Tuskegee' Doctor in Guatemala, 1946-48."

Her website bio states, "She has competed two books on what is referred to as the infamous "Tuskegee" Syphilis study (1932-72), the longest running non-therapeutic research study in U.S. history that involved the United States Public Health Service and more than 600 African American men in the counties surrounding Tuskegee, Alabama. The men thought they were being "treated," not studied, for what they thought of as "bad blood." The study has become a central metaphor for distrust of the health care system and as the key example of unethical research. She was a member of the Legacy Committee on the Tuskegee Syphilis Study that successfully lobbied President Bill Clinton to offer a public apology to the surviving men and their heirs in l997. Her edited book of articles and primary documents on the study appeared in 2000 (Tuskegee Truths: Rethinking the Tuskegee Syphilis Study). Her new book, Examining Tuskegee: The Infamous Syphilis Study and its Legacy came out in 2009. It won the Arthur Viseltear Prize from the Medical Care Section of the American Public Health Association in 2010. Please see the following website for more information: http://www.examiningtuskegee.com."

Reverby's full pre copy-edited article notes, "The story of the work in Guatemala also confirms that fact about noninfecting in the 'Tuskegee' Study, since it shows the difficulty of infecting individuals with syphilis in a scientific project. The lengths that Cutler and his colleagues had to go to give the disease to the inmates of the asylum, prison and army barracks in Guatemala, and then later in less atrocious ways at Sing Sing, provides us with a way to say this is not what happened in Tuskegee."

From the synopsis, Reverby adds,

In 1946-48, Dr. John C. Cutler, a PHS

physician who would later be part of the Syphilis Study in Alabama

in the 1960s and continue to defend it two decades after it ended in

the 1990s, was running a syphilis inoculation project in Guatemala,

co-sponsored by the PHS, the National Institutes of Health, the Pan

American Health Sanitary Bureau (now the Pan American Health

Organization), and the Guatemalan government.


Cutler and the other physicians chose men in the Guatemala

National Penitentiary, then in an army barracks, and men and

women in the National Mental Health Hospital for a total of 696

subjects. Permissions were gained from the authorities but not

individuals, not an uncommon practice at the time, and supplies

were offered to the institutions in exchange for access. The doctors

used prostitutes with the disease to pass it to the prisoners (since

sexual visits were allowed by law in Guatemalan prisons) and then

did direct inoculations made from syphilis bacteria poured onto the

men’s penises or on forearms and faces that were slightly abraded

when the “normal exposure” produced little disease, or in a few cases

through spinal punctures. Unlike in Alabama, the subjects were then

given penicillin after they contracted the illness. However, whether

everyone was then cured is not clear and not everyone received what

was even then considered adequate treatment.

Yet the PHS was aware then that this was a study that would

raise ethical questions. For as Surgeon General Thomas Parran made

clear “’You know, we couldn’t do such an experiment in this

country.”4 Deception was the key here as it had been in Tuskegee.

Much of this was kept hushed even from some of the Guatemalan

officials and information about the project only circulated in selected

syphilology circles. When it proved difficult to transfer the disease

and other priorities at home seemed more important, Cutler was told

to pack up and come back to the States.

She also refers to experimentation done in American prisons, sometimes without prisoners' consent,

In 1944 the PHS had done experiments on prophylaxis in

gonorrhea at the Terre Haute Federal Penitentiary in the United

States. In this prison, the “volunteers” were deliberately injected with

gonorrhea (which can be cultured), but the PHS had found it difficult

to get the men to exhibit infection and the study was abandoned.

A footnote references "Subjects or Objects? Prisoners and Human Experimentation" by Dr. Barron H. Lerner, an associate professor of medicine and public health at Columbia University, New York.

During the 1950s, inmates at what was then called Holmesburg Prison, in Philadelphia, were inoculated with condyloma acuminatum, cutaneous moniliasis, and viruses causing warts, herpes simplex, and herpes zoster. (1) For participating in this research, and in studies exposing them to dioxin and agents of chemical warfare, they were paid up to $1,500 a month. Between 1963 and 1971, researchers in Oregon and Washington irradiated and repeatedly took biopsy specimens from the testicles of healthy prisoners; the men subsequently reported rashes, peeling, and blisters on the scrotum as well as sexual difficulties. (2) Hundreds of such experiments induced the federal government to essentially ban research involving prisoners in 1978. The message: such research is fundamentally exploitative and thus unethical.

Yet a recent report by the Institute of Medicine (IOM) has opened the closed door, arguing not only that such research can be performed appropriately but that prisoners deserve to be included in investigative studies -- at least those who might benefit directly. Examination of the explanations behind U.S. restrictions on prison research and their current applicability can provide guidance for today's policy debates.


World War II turned questionable experimentation on prisoners into a cottage industry. As other Americans risked their lives on the battlefield, prisoners did their part by participating in studies that exposed them to gonorrhea, gas gangrene, dengue fever, and malaria.(1) Any consideration of meaningful consent was subsumed by the war imperative.

Ironically, the biggest boost to such experimentation came as a result of the postwar Nuremberg trial of 20 Nazi doctors, which gave rise to the Nuremberg Code, a set of principles intended to prohibit human experimentation without subjects' consent. When defense lawyers implied that American scientists had conducted wartime research analogous to that of the Nazis, one prosecution witness, Andrew C. Ivy, cited malaria experiments involving Illinois prisoners as an example of "ideal," noncoercive research. Ivy's 1948 publication of his conclusions helped to institutionalize prison experimentation for the next quarter-century.(4)

From Reverby's synopsis,

It was an experiment involving another vulnerable population that halted the prison research enterprise. In 1972, an Associated Press reporter broke the story that poor southern black men with syphilis had been deliberately left untreated for 40 years so researchers could study the natural course of the disease. In the environment created by the civil rights movement and protests against the Vietnam War, such research was condemned. The scandal led to the formation of the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research and eventually the Belmont Report, which recommended revamping human experimentation using the principles of respect for persons, nonmaleficence, and justice.

In the case of prison research, the new atmosphere proved especially restrictive. In 1978, the Department of Health and Human Services (DHHS) passed regulations that limited federally funded research involving prisoners in several ways, stipulating, for example, that experiments could pose no more than minimal risk to the subjects. The overarching concern was that prisons were inherently coercive environments in which informed consent could never be obtained. The fact that research offered financial rewards, alleviation of boredom, and the prospect of earlier parole made it even more dicey.


It is often said that those who ignore history are condemned to repeat it. But a decision to retain current restrictions because of past abuses would ignore several important developments. Since 1978, a network of institutional review boards has been established at the National Institutes of Health, other governmental agencies, and research universities throughout the country. With "informed consent" now common parlance, study subjects are more aware of their rights. And, largely owing to the work of AIDS activists and breast cancer activists, sick and at-risk persons, even those from potentially vulnerable populations, now actively pursue participation in research protocols. Even though not all these developments are unambiguously positive, to ignore them and the opportunities they may afford prisoners would be to regress. As the IOM report said, "Respect for prisoners also requires recognition of their autonomy."

Last December, in an article published at Huffington Post, Reverby wrote about how false reporting on the Tuskegee experiments was causing many African-Americans to distrust doctors.

Rumors and myths about what happened continue to circulate in whispers, blogs and media coverage. Most egregious in the face of the need for H1N1 vaccine is the erroneous claim that the government's doctors intentionally infected the men with syphilis. But no "Tuskegee experiment syphilis vaccine" was ever created; no shots of the bacteria that cause syphilis were put into the men's veins.

As the Obama administration takes on the huge task of reforming how we organize and pay for health care for all Americans and we line up for our shots, "Tuskegee" can offer another perhaps less obvious, if ironic, lesson. These men living in rural Alabama came forward for treatment not because they were uneducated and easily duped by their government, but because they needed health care for themselves and their families. They, as with increasing numbers of Americans, had no real access to the medical care they required, could not pay for what was available, and had to find it where possible.

Perhaps as the debate over health care reform winds its way through the Congress, a new post on Twitter should read: "Don't forget the 'Tuskegee' syphilis study. Everyone deserves the right to affordable health care and this is what our government should and must provide."

Secretary of State Hillary Clinton and Health Secretary Kathleen Sebelius call study conducted between 1946 and 1948 in Guatemala 'clearly unethical' and 'reprehensible'

AFP reports,

The United States apologized Friday for funding a 1940s study in which hundreds of Guatemalans were deliberately infected with syphilis and gonorrhea without their consent.

The study conducted between 1946 and 1948 in Guatemala was "clearly unethical" and "reprehensible," said Secretary of State Hillary Clinton and Health Secretary Kathleen Sebelius in a statement.

The researchers who conducted the study enrolled vulnerable populations including mental patients, and did not inform them of the intent of the study or what would happen to them. The participants were encouraged to pass on sexually transmitted diseases, and some who contracted syphilis were not treated.

A total of some 1,500 people took part in the study. At least one patient died during the experiments, although it is not clear whether the death was from the experiments or from an underlying medical problem.

"Although these events occurred more than 64 years ago, we are outraged that such reprehensible research could have occurred under the guise of public health," Clinton and Sebelius said.

"We deeply regret that it happened and we apologize to all the individuals who were affected by such abhorrent research practices," they said, announcing the launch of a thorough investigation into the specifics of the study.

"The sexually transmitted disease inoculation study conducted from 1946-1948 in Guatemala was clearly unethical."

The aim of the Guatemala study, which was funded by a grant from the US National Institutes of Health to the then Pan American Sanitary Bureau, which became the Pan American Health Organization, was to look for new ways to prevent sexually transmitted diseases.

The first experiments in Guatemala involved infecting female commercial sex workers with gonorrhea or syphilis, and then allowing them to have unprotected sex with soldiers or prison inmates.

"When few of these men became infected, the research approach changed to direct inoculation of soldiers, prisoners and mental hospital patients," background documents on the study show.

(with AFP report)