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Single dose of vaccine may prevent cervical cancer: researchers

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A single vaccine shot, rather than the recommended triple dose, may be enough to protect women against cervical cancer, a study said on Wednesday.

If further work validates the findings, there could be major gains for campaigns to vaccinate young women in poor countries, the authors said.

The research looked at Cervarix, which with another vaccine, Gardasil, is being rolled out to shield young girls from the human papillomavirus (HPV) which causes cervical cancer.

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Cervarix is a so-called bivalent vaccine, targeting two types of virus — HPV 16 and 18 — that together are to blame for about 70 percent of cases.

The vaccine was initially approved to be given in three doses over six months, although some countries have cautiously switched to a two-dose schedule.

The new research, published in the journal The Lancet Oncology, suggests that this easier regimen could be taken even further.

The authors reported on an aspect of two big trials to test Cervarix among 7,500 women in Costa Rica aged 18-25 and more than 18,500 women aged 15-25 in the Asia-Pacific, Europe and the Americas.

Women in these trials were randomly assigned to receiving either Cervarix in three doses, or a hepatitis A vaccine.

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However, 543 of the women in the Cervarix group only received one dose, mainly because their vaccination was discontinued due to pregnancy.

Four years after the trial took place, the researchers checked the health of the volunteers.

They found there was no difference in cancer rates among those who had received Cervarix, regardless of the number of doses they had received.

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The authors, led by Cosette Wheeler of the University of New Mexico in Albuquerque, call for a new randomised study to see if these findings hold true on a larger scale and beyond just four years.

If the good news is confirmed, the big beneficiaries would be poor countries.

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Cervical cancer is notoriously called a “silent killer” of women. It is the fourth commonest cause of cancer among women, and tragically is often diagnosed too late.

“If one dose is sufficient, it could reduce vaccination and administration costs as well as improve uptake,” said co-author Aimee Kreimer of the US National Cancer Institute.

“This is especially important in less developed regions of the world, where more than 80 percent of cervical cancer cases occur.”

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HPV is easily spread by sexual intercourse.

In addition to cervical cancer, it can also cause genital warts and cancer of the anus and penis. For that reason, doctors in the United States and other countries recommend pre-teens of both sexes be vaccinated.


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World leaders mocked Trump because they’re tired of his ‘center of attention’ act: MSNBC guest

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During an MSNBC segment on President Donald Trump's abrupt departure from NATO talks in London after video was released of world leaders making fun of him, an MSNBC guest said those same leaders have become tired of his act.

Speaking with host David Gura, the LA Times Eli Stokols said international diplomats have realized there is no dealing with the president who is in his own world and just wants attention..

"Your colleague had a great line: 'This is a president who views norms like a teenager views curfews,'" Gura began.

"Well, he likes going to these things and blowing them up and being the center of attention," Stokols replied.

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Trump slammed for lawless obstruction of Congress: ‘He’s taken a sledgehammer to the Constitution’

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On CNN Saturday, former Rep. Elizabeth Holtzman (D-NY), who voted for the articles of impeachment against President Richard Nixon, discussed the path forward for impeaching President Donald Trump.

"We know moderate Democrats are a bit frustrated with leadership over potentially expanding the scope of their consideration, maybe the Mueller report findings and drawing up these articles of impeachment," said anchor Victor Blackwell. "Do you think it's a mistake not to include anything beyond the Ukraine matter?"

"Yes," said Holtzman. "I think it would be a mistake, although, you know, I'm still at a distance, and the members of the committee really have to, who have been digging into this deeply have the best feel, but my sense is that the, what the president did is so egregious, not just with regard to Ukraine, but what part of what's bad about his activities in Ukraine, is that he's taken a sledgehammer to the Constitution by saying that Congress has no right to get information, and he's cut off his committee, his administration from, and ordered and directed them not to cooperate with the committee in any way."

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CNN

Giuliani pummeled by ex-press secretary for ‘returning to the scene of the crime’ to create Ukraine chaos

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On CNN Saturday, Rudy Giuliani's former mayoral press secretary Ken Frydman harshly criticized his former boss for his ongoing efforts in the Ukraine scheme.

"As you've watched the former mayor over the last several years, have you identified a point at which things shifted for the man who I guess still is for some known at America's Mayor?" asked anchor Victor Blackwell."

"Well, yeah. I think when he went into business with Donald Trump," said Frydman. "You saw a — a severe change in his personality. He had a zealous need to make money, to be relevant. To be part of the political process. And you know right now he's making, I think, ill-advised decisions, like returning to the scene of the crime, Ukraine, to make a propagandist documentary. Almost as if he's playing, he and the president, are playing, 'catch me if you can.' The president will not participate in the impeachment hearings, and Rudy is off in the Ukraine doubling down."

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