Over the course of a year, taking cranberry capsules did nothing to stave off urinary tract infections (UTIs) among older women living in nursing homes, a U.S. study finds.
Women taking the capsules had just as many UTIs and infection-promoting factors in their urine as women taking inert placebo pills, researchers conclude.
“I think it reinforces what many of the other studies have said so far,” said lead author Dr. Manisha Juthani-Mehta, of the Yale School of Medicine in New Haven, Connecticut.
Previous studies on the use of cranberry products like juice and capsules produced mixed results. A systematic look at that evidence published in 2012 by the Cochrane Collaboration, an international organization that evaluates and reviews medical research, concluded “cranberry juice cannot currently be recommended for the prevention of UTIs.”
Originally, it was thought that eating or drinking cranberry products increased the acidity of urine and prevented UTIs. There was also speculation that a compound in cranberries known as proanthocyanidin prevented bacteria from adhering to the bladder wall.
For the new study, the researchers randomly assigned 185 women over 65 years old living in 21 nursing homes near Yale to take pills every day. The participants received either two capsules containing cranberry extracts including a total of 72 milligrams of proanthocyanidin, the equivalent of a person drinking a 20-ounce bottle of cranberry juice, or they got look-alike dummy pills.
At the start of the study, about a third of the women had positive urine tests for bacteria and white blood cells, which doesn’t mean the women had UTIs but these are needed elements for an infection to occur.
The researchers had a year of data on 147 women. The other women either died, withdrew from the study or were discharged from the nursing home.
Overall, there was no difference between women who took cranberry pills or placebos in the proportion who had bacteria and white blood cells in their urine at the end of the study period. Additionally, there was no difference between the two groups in the share of women who experienced symptomatic UTIs, died, were sent to hospitals or used antibiotics.
The results were published in JAMA to coincide with their presentation at the infectious disease conference known as IDWeek, which is being held in New Orleans.
“It is time to move on from cranberries,” writes Dr. Lindsay Nicolle in an editorial accompanying the new study.
“The continuing promotion of cranberry use to prevent recurrent UTI in the popular press or online advice seems inconsistent with the reality of repeated negative studies or positive studies compromised by methodological shortcomings,” writes Nicolle, of the University of Manitoba in Winnipeg, Canada.
Juthani-Mehta told Reuters Health that there is probably little downside to people eating or drinking cranberry products if they like, but she wouldn’t recommend those as a way to prevent UTIs – especially among older adults who may be on a fixed income.
“Capsules can range from not a lot of money to $200 per month for a 30-day supply,” she said.
For UTI prevention, Juthani-Mehta said there are a couple approaches people – especially women – can take, including making sure they stay hydrated.
“In terms of prevention, hydration is certainly important,” she said. “The other factor in post-menopausal women is topical estrogen therapy among women who had recurrent UTIs. It has shown some benefit.”
“We may not have a study to say drinking water can prevent UTIs, but that’s really what I recommend,” she said.
SOURCE: http://bit.ly/2eKztGl and http://bit.ly/2eKABtx JAMA, online October 27, 2016.
WATCH: New Zealand prime minister unfazed as quake hits during an interview
A moderate 5.6-magnitude earthquake rattled New Zealand's North Island early Monday but failed to crack Prime Minister Jacinda Ardern's trademark composure as she conducted a live television interview.
The quake struck just off the coast before 8:00 am local time (2000 Sunday GMT) at a depth of about 52 kilometres (32 miles) near Levin, about 90 kilometres north of Wellington, the US Geological Survey said.
St John Ambulance and New Zealand Police both said there were no initial reports of injuries or damage. There was no tsunami warning.
But there was sustained shaking in Wellington, where Ardern was being interviewed on breakfast television from parliament's Beehive building, which is designed to absorb seismic forces by swaying slightly on its foundations.
US farmers are starting to worry as crop prices dip during COVID-19 crisis: ‘It’s kind of glum’
Dave Burrier steered his tractor through a field, following a GPS map as he tried to plant as much corn as possible amid the yellow and green rye covering the ground.
Striving to get a massive yield out of his crops in rural Maryland is how Burrier hopes to make it through yet another uncertain year, beset by market disruptions caused by the COVID-19 pandemic and renewed trade tensions between the United States and China.
"We've had so much price erosion that we're basically at below the cost of production. We've got to figure out how to manage and turn a profit," Burrier told AFP.
‘It’s the first time I’ve played golf in almost 3 months’: Trump makes excuses for golfing during coronavirus pandemic
President Donald Trump was blasted on Sunday for playing golf during the coronavirus pandemic, a dramatic economic recession and after proclaiming churches "essential."
Instead of joining his voters sitting in the pews, Trump went for the links, which drew criticisms for the hypocrisy.
"Sleepy Joe’s representatives have just put out an ad saying that I went to play golf (exercise) today. They think I should stay in the White House at all times. What they didn’t say is that it’s the first time I’ve played golf in almost 3 months, that Biden was constantly vacationing, relaxing & making shady deals with other countries, & that Barack was always playing golf, doing much of his traveling in a fume spewing 747 to play golf in Hawaii - Once even teeing off immediately after announcing the gruesome death of a great young man by ISIS!" tweeted Trump.