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Groundbreaking study uncovers protein that keeps skin youthful

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Beauty might only be skin deep, but for those wondering how to keep that skin young, scientists may have found an answer in the form of a protein that encourages cell competition.

The prosaically named COL17A1 might not sound like a fountain of youth, but the new study suggests it does the heavy lifting when it comes to keeping skin intact and unimpaired.

The protein works by encouraging cell competition, a key process to maintain tissue fitness. That effectively “drives out” weaker cells while encouraging replication of stronger ones.

But ageing results in a depletion of COL17A1, as do familiar enemies of youthful skin, like UV radiation.

And when that happens, weaker cells replicate, leaving the skin thinner, more prone to damage and slower to heal.

The research published Thursday in the journal Nature is based on investigations using mice tails, which share many of the same characteristics as human skin.

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After confirming the importance of COL17A1, the team decided to investigate whether they could stimulate the protein once it was depleted — effectively looking for compounds that could kickstart the anti-ageing process in skin.

They isolated two chemical compounds — Y27632 and apocynin — and tested both on skin cells, with positive results.

“Application of these drugs to full-thickness skin wounds significantly promoted wound repair,” the study said.

The two compounds point to ways of “facilitating skin regeneration and reducing skin ageing,” the study added.

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In a review of the study commissioned by Nature, two professors from the University of Colorado said cell competition had previously only been studied extensively in fruit flies.

The research “provides evidence that healthy cells in mammals can also efficiently repopulate adults tissues, replacing unfit or damaged cells,” wrote professors Ganna Bilousova and James DeGregori.

And they said the research offered “proof-of-principle” that the two chemical compounds could combat ageing.

“Future studies are needed to determine the mechanisms of cell competition in other tissues, and to identify compounds capable of reversing ageing in other organs,” they said.

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‘Everyone ultimately prefers their own race’: Morrissey claims he’s not racist because everybody else is

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Former Smiths singer Morrissey explained in an interview that he couldn't possibly be a racist because everyone else is racist.

Morrissey came out for the anti-Islam political party in England, and has run into problems about his political claims ever since. As noted by Consequence of Sound, "it doesn’t help that he says thing like Halal certifiers support ISIS, of course."

He made the comments as part of an interview with his own nephew Sam Etsy Rayner, for Moz’s website.

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Here is how Republicans are reacting when confronted with the new rape allegation against Trump

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Once again, President Donald Trump has been accused of a sexual assault — one of the most severe charges yet, in fact — and yet the Republican Party continues to make clear that it will not take these allegations seriously.

Journalist E. Jean Carroll detailed her account of Trump raping her in a Bergdorf Goodman dressing room more than two decades ago in an article, in her new book, and in TV interviews. New York Magazine reported that it contacted two of her friends who confirmed that she told them about the assault shortly after it happened.

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‘He should be hospitalized’: Internet stunned after Trump goes off on completely incoherent Mt Rushmore rant

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President Donald Trump was asked on Tuesday whether his face should appear on Mount Rushmore along with other major American presidents.

“If I answer that question yes, I will end up with such bad publicity,” Trump told The Hill, before pivoting to an incoherent rant about fireworks.

The president's rambling shocked many people on Twitter:

Apart from Trump’s apparent inability to string together coherent English sentences on the fly, note also the sheer ignorance and apathy toward the idea that there might be legitimate reasons why fireworks are not detonated around the Black Hills. https://t.co/jja2XD19Mw

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