Last year, Biden nominated Denver International Airport CEO Phil Washington to serve as FAA administrator. A spokesperson for Washington at the airport did not immediately comment.
Transportation Secretary Pete Buttigieg late Saturday confirmed Washington's withdrawal first reported by Reuters.
"The partisan attacks and procedural obstruction he has faced are undeserved, but I respect his decision to withdraw and am grateful for his service," Buttigieg said on Twitter.
The agency has faced numerous safety questions in recent months after a series of close-call safety incidents and the Senate Commerce Committee earlier this week delayed a vote on his nomination citing outstanding questions by some lawmakers. Sen. Kyrsten Sinema, an independent, had not announced whether she would support him and Sen. Jon Tester, a Democrat, also was still considering how to vote, a spokeswoman said this week.
Sen. Ted Cruz, ranking Republican on the Senate Commerce Committee, said late Saturday that it has been clear since his nomination that "Mr. Washington lacked the aviation experience necessary to run the FAA ... The Biden administration must now quickly name someone to head the FAA who has an extensive aviation background, can earn widespread bipartisan support in the Senate, and will keep the flying public safe."
Cruz and other Republicans had said Washington, who retired from the U.S. Army in July 2000, needed a waiver from rules requiring civilian leadership to head the FAA. The Transportation Department's general counsel said Washington was fully qualified and did not need a waiver.
Cruz noted Washington has only about two years of experience as an airport CEO and criticized Washington's inability to answer some aviation questions at his confirmation hearing.
The White House insisted Washington was fully qualified. Cantwell had said he would shakeup the agency saying "we feel that industry and FAA got too cozy."
A White House official had earlier told Reuters "politics must not hold up confirming an administrator to lead the FAA, and we will move expeditiously to nominate a new candidate for FAA administrator."
The official said "an onslaught of unfounded Republican attacks on Mr Washington’s service and experience irresponsibly delayed this process, threatened unnecessary procedural hurdles on the Senate floor, and ultimately have led him to withdraw his nomination today."
Washington was originally nominated in July but did not get a hearing from the Commerce Committee until March 1.
The FAA has had a number of recent safety issues.
In January, the FAA halted all departing passenger airline flights for nearly two hours because of a pilot messaging database outage, the first nationwide ground stop of its kind since the Sept. 11, 2001, attacks.
On Wednesday, the FAA issued a safety alert to airlines, pilots and others about the "need for continued vigilance and attention to mitigation of safety risks" after a series of high-profile near collisions.
Six serious runway incursions have occurred since January that prompted the agency to convene a safety summit last week.
Some industry officials think the White House could name acting FAA Administrator Billy Nolen as a new nominee. Nolen, who was named head of the FAA's aviation safety office, has been the acting FAA administrator since April 2022 and has received backing from many Republicans in Congress.
Washington had won support from a wide range of groups, including a number of aviation unions and a group of family members of some killed in a 2019 fatal Boeing 737 MAX crash.
The FAA has been without a permanent administrator for almost a year.
This was the second major Bide nominee to withdraw in recent weeks. Gigi Sohn, his pick for a key fifth seat on the Federal Communications Commission (FCC), withdrew dealing a setback for Democrats who have been unable to take control of the telecom regulator for more than two years.
(Reporting by David Shepardson, editing by Deepa Babington and Marguerita Choy, Robert Birsel)