Humans have a “natural” lifespan of around 38 years, according to a new method we have developed for estimating the lifespans of different species by analysing their DNA.
Extrapolating from genetic studies of species with known lifespans, we found that the extinct woolly mammoth probably lived around 60 years and bowhead whales can expect to enjoy more than two and a half centuries of life.
Our research, published today in Scientific Reports, looked at how DNA changes as an animal ages – and found that it varies from species to species and is related to how long the animal is likely to live.
The mystery of ageing
The ageing process is very important in biomedical and ecological research. As animals grow older, they experience a decline of biological functions, which limits their lifespan. Until now it has been difficult to determine how many years an animal can live.
DNA is the blueprint of living organisms and it is an obvious place to seek insights into ageing and lifespan. However, no-one has been able to find differences in DNA sequences that account for differences in lifespans.
Lifespans among vertebrates varies greatly. The pygmy goby (Eviota sigillata) is a small fish that lives only eight weeks, whereas individual Greenland sharks (Somniosus microcephalus) have been found that lived for more than 400 years.
Knowing the lifespan of wild animals is fundamental for wildlife management and conservation. For endangered species, lifespan can be used to understand what populations are viable. In industries such as fisheries, lifespan is used in population models to determine catch limits.
However, the lifespan of most animals is unknown. Most estimates come from a small number of individuals living in captivity whose ages at death were known. For long-lived species it is difficult to obtain a lifespan as they may outlive a generation of researchers.
Using changes in DNA to measure age
Over the past few years researchers have developed DNA “clocks” that can determine how old an animal is using a special type of change in the DNA called DNA methylation.
DNA methylation does not change the underlying sequence of a gene but controls whether it is active. Other researchers have shown that DNA methylation in specific genes is associated with the maximum lifespan of some mammals such as primates.
Despite DNA methylation being linked to ageing and lifespan, no research until now has used it as a method to estimate the lifespan of animals.
In our research, we have used 252 genomes (full DNA sequences) of vertebrate species that other researchers have assembled and made publicly available in an online database. We then compared these genomes to another database of known animal lifespans.
Using this data, we found that we could estimate the lifespan of vertebrate species by looking at where DNA methylation occurs in 42 particular genes. This method also lets us estimate the lifespans of long-lived and extinct species.
We found the lifespan of the bowhead whale, thought to be the world’s longest lived mammal, is 268 years. This estimate is 57 years higher than the oldest individual that has been found, so they may have a much longer lifespan than previously thought.
We also found the extinct woolly mammoth had a lifespan of 60 years, similar to the 65-year span of the modern-day African elephant.
The extinct Pinta Island giant tortoise had a lifespan of 120 years by our estimate. The last member of this species, Lonesome George, died in 2012 at age 112.
Interestingly, we found Neanderthals and Denisovans, which are extinct species closely related to modern humans, had a maximum lifespan of 37.8 years.
Based on DNA, we also estimated a “natural” lifespan modern humans of 38 years. This matches some anthropological estimates for early modern humans. However, humans today may be an exception to this study as advances in medicine and lifestyle have extended the average lifespan.
As more scientists assemble the genomes of other animals, our method means their lifespans can readily be estimated. This has huge ecological and conservation significance for many species which require better wildlife management.
Chief Justice Roberts admonishes lawyers at Senate impeachment trial
Chief Justice of the United States Supreme Court John Roberts made his first major intervention in President Donald Trump's impeachment trial shortly before 1 a.m. Wednesday morning.
After House Intelligence Committee Chairman Adam Schiff (D-CA) finished his closing arguments on why former National Security Advisor John Bolton should testify, the White House team went on the attack. Yelling and demanding apologies, the president's team was more animated than they'd been all night. Roberts then admonished the House and White House on their language.
Claiming the Senate is the "world's greatest deliberative body" -- despite what he had witnessed during 12 hours of the impeachment trial -- Roberts complained about language that was "not conducive to civil discourse."
White House lawyers begin yelling at Democrats during late-night impeachment trial — after Trump starts tweeting
President Donald Trump woke up and began tweeting around midnight EST during the Senate impeachment trial over the amendments over the rules. That's when a noticeable thing changed on the Senate floor: Trump's team started yelling.
Nearing 1 a.m. EST Tuesday morning while the president was tweeting about impeachment, his team began attacking Rep. Jerry Nadler (D-NY) personally. They called him a liar and accused him of attacking the president and demanded an apology. After nearly 12 hours this was the first time the White House got even remotely animated after a dull defense of the president.
Mick Mulvaney released treasure trove of OMB documents — 2 minutes before midnight
Office of Management and Budget (OMB) Director Mick Mulvaney released a huge cache of documents on Tuesday evening -- minutes before the midnight deadline.
The documents were released to the ethics group American oversight, which had pursued a Freedom of Information Act lawsuit against the department.
"Two minutes before midnight, OMB released 192 pages of Ukraine-related records to American Oversight, including emails that have not been previously released," American Oversight announced.
"The files released tonight include emails sent by OMB Acting Director Russell Vought and Assoc Director for National Security Michael Duffey — two key players in the withholding of Ukraine aid — in on the morning of President Trump’s July 25 call with President Zelensky," the ethics group noted.