Issa has represented California's 49th congressional district, a coastal seat between San Diego and Orange County.
Here is a look back at some of the most embarrassing moments during Issa's two decades in politics.
No comment, but here's a middle finger
In May, Politico's Rachael Bade attempted to ask Congressman Issa about reports President Donald Trump asked then-FBI director James Comey to stop investigating former National Security Adviser Michael Flynn.
Issa allegedly refused to answer the question, flipped the bird and kept walking.
Congressman hides on roof to avoid angry constituents
Also in May, Issa was spotted hiding on the roof of his district office building, looking down upon hundreds of protesters.
&ref_url=https%3A%2F%2Fwww.rawstory.com%2F2017%2F05%2Fendangered-gop-lawmaker-darrell-issa-hides-out-on-roof-while-avoiding-angry-constituents%2FCrowd boos after Issa mocks woman claiming to be battered by one of his aides
In March, Issa dismissed and then mocked a constituent at a contentious San Diego town hall meeting.
“I had a very small sign that said, ’Investigate Russia now,'” the woman, a member of the State Bar of California claimed. "You bodyguard, security guard, came over and took my sign away from me forcibly. I asserted my 1st Amendment rights of free speech. I told him it was suppression of speech.”
“Well, okay” the congressman said as her mic was taken away. “We’ll go on to somebody who doesn’t have a pending lawsuit. Next!”
Honoring Nazis to honor America's veterans
In 2014, Congressman Issa launched a Twitter campaign to showcase and honor American veterans.
In response, Issa also received photos of Nazi Reichsführer-SS Heinrich Himmler, JFK assassin Lee Harvey Oswald, convicted My Lai massacre war criminal William Calley, and Oklahoma City bomber Timothy McVeigh, all of which were posted on Issa’s timeline.
Attorney General scolds Issa for 'inappropriate' and 'shameful' conduct
In 2013, Attorney General Eric Holder testified before the House Judiciary Committee, when Congressman Issa tried to interrupt him.
“No, no, that’s what you typically do,” the attorney general shot back. “No, I’m not going to stop talking now.”
“It is inappropriate and too consistent with the way in which you conduct yourself as a member of Congress,” Holder lectured. “It is unacceptable and it’s shameful.”
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