His mother Mamie Till-Mobley, who became an activist after the murder and is credited with having helped spark the US civil rights movement, will also be remembered in the national memorial.
"The new monument will protect places that tell the story of Emmett Till's too-short life and racially-motivated murder, the unjust acquittal of his murderers, and the activism of his mother," the White House said.
The memorial proclamation will be unveiled by Biden in the ornate Indian Treaty Room at the White House, with the last surviving witness to Till's fatal abduction in attendance.
Wheeler Parker, a pastor now in his 80s, was Till's best friend and cousin when, aged 16, he witnessed him be taken away to his death. The White House said Parker would be joined by about 60 other guests, including Till family members, civil rights leaders and senior government officials.
Signed on the 82nd anniversary of Till's birth, Biden's proclamation will preserve three historic sites in Illinois and Mississippi.
One of them will be the Roberts Temple Church of God in Christ in Chicago, where Till's mother insisted at her son's funeral that the casket remain open, allowing a huge crowd and the press to see the boy's disfigured body -- a moment that galvanized public outrage.
Another will be the Tallahatchie, Mississippi, courthouse where an all-white jury found the men accused of murdering Till not guilty. (They would later admit to the crime.)
The third location will be the spot on the Tallahatchie River in Mississippi where Till's battered body was eventually discovered. Signs commemorating the brutal event there and in other locations around Tallahatchie County have repeatedly been defaced and vandalized over the years.
- New slavery controversy -
Biden's high-profile treatment for a painful piece of 20th century US history is playing out against a backdrop of accusations that a leading Republican candidate for the 2024 presidential race is openly stirring racist sentiment.
Florida Governor Ron DeSantis has led a charge to minimize the history of past racism in his state's school curriculum, making this part of a broader campaign against what he describes as the "virus" of "woke" left-wing values.
Responding to an outcry over what has been described as an attempt to rewrite history, DeSantis last week doubled down, saying that slaves in some instances learned valuable skills.
"They're probably going to show that some of the folks that eventually parlayed, you know, being (an enslaved) blacksmith into doing things later in life," DeSantis said Friday.
White House Press Secretary Karine Jean-Pierre described DeSantis's comment as "inaccurate" and "insulting."
"It's hurtful and prevents an honest account, an honest account of our nation's history," she said.
Jean-Pierre, who is Black, said the Emmett Till monument was part of "the broader story of American Black oppression" and survival.
"It's an important moment. You're going to hear directly from the president," she said.
